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Lipo2000 br Western blot assay br For
2020-08-12
4.4. Western blot assay For Western blot analysis, Lipo2000 were treated with the indicated concentrations of drugs for 24 and 48 h and then harvested by scraping with lysis buffer (1 mM EGTA, 1 mM EDTA, 150 mM NaCl, 1% Triton X-100, 2.5 mM sodium pyrophosphate, 1 mM PMSF, 1 mM Na3VO4, 1 μg
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br Fig Phenotype screening method Left panel After five
2020-08-07
Fig. 1. Phenotype screening method. (Left panel) After five baseline measurements were taken, a test sample was injected. Next, changes in OCR and ECAR were simultaneously monitored for 1 h, followed by measurements using the Seahorse XF Cell Mito Stress Test kit. Oligomycin A (OMA), FCCP, and rot
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br The OS rate after the first
2020-08-07
The OS rate after the first metastasectomy for the first recurrence was defined as the interval from the date of the first metastasectomy to any-cause mortality or the date of the last follow-up (Fig. 1). The recurrence-free survival (RFS) after the surgical resection for the initial recurrence (R
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br Conclusion br In conclusion we developed a target
2020-08-07
5. Conclusion In conclusion, we developed a target drug delivery system to en-hance cancer targeting under a static magnetic field and laser irradia-tion to inhibit tumor growth. The system was demonstrated to be ef-fective for the synchronization of in situ transdermal administration, a magnet
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br Total ATP Glucose Uptake and
2020-08-07
Total ATP, Glucose Uptake and Lactate Secretion Glucose uptake and total ATP were measured on cells seeded in white 96-well plates (5000 cells/well) (Glucose uptake-Glo J1342, Cell-Titer-Glo, G7571, Promega). Extracellular lactate secretion was measured by collecting medium from 5000 cells cult
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Geneticin, G-418 Sulfate br Pre segmentation of test cells
2020-08-07
3.3. Pre-segmentation of test cells A test cell was defined as a cell for which we wished to check the possible reconstruction of its expected shape. Moreover, we wanted to assess the quality of the reconstruction and parameters characterizing the overlapped area of the deformed cells. The f
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br Conclusions br This is the first study to investigate
2020-08-06
Conclusions This is the first study to investigate the relationship between nicotine dependence and genotypes according to smoking status in Chinese patients with lung cancer. Health care workers should pay attention to the duration of smoking and the initial age of smoking of patients who fail
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br The primary limitations of this
2020-08-06
The primary limitations of this trial are retrospective design and the low number of centers involved (2 centers). Another limitation could be the Fosfomycin calcium that higher rate of IRAEs reflects higher treatment exposure and no T-cell activation. To define this point, we analyzed the n
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br Conclusions br Our findings suggest that among women
2020-08-05
4. Conclusions Our findings suggest that, among women aged 50 or younger who underwent oophorectomy as part of surgical treatment for endometrial cancer, BMI is inversely related to complaints of menopausal symptoms. We identified a precipitous decline in the frequency of symptoms rang-ing from
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br Figure In ovo efficacy
2020-08-04
Figure 3. In ovo efficacy of 8a compared to DOX after two intratumoral injections of each drug (20 nmol) twice a day for two consecutive days, white arrows indicate the tumors, scale bar: 0.5 cm. (A) left: tumor before injection of DOX; right: tumor three days post injection of DOX (50 % tumor reg
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P Gupta M P Bansal A Koul Spectroscopic characterization of
2020-08-02
[4] P. Gupta, M.P. Bansal, A. Koul, Spectroscopic characterization of lycopene extract from Lycopersicum esculentum (Tomato) and its evaluation as a chemopreventive agent against experimental hepatocarcinogenesis in mice, Phytother. Res. 27 (2013) 448–456. [5] T. Eluvakkal, S.R. Sivakumar, K. Arunk
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Methoxy-X04 br The effect of green tea polysaccharide on the
2020-07-31
3.6. The effect of green tea polysaccharide on the growth of PC-3 Methoxy-X04 and apoptotic protein expression To study the effect of cytotoxic activity of GTP on cell viability, PC-3 cells were treated with increasing concentrations of GTP (25, 50 and 100 μg/ml). After 48 h, growth of PC-3 ce
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br All animal studies were approved
2020-07-30
All animal studies were approved by the Laboratory Animal Welfare and Ethics Committee of the Third Military Medical University. Male BALB/c nude mice (5–7 weeks of age) were purchased from Chongqing Byrness Weil Biotechnology Co., Ltd. (Chongqing, China). Each animal was housed under standard con
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br Conclusion Mar C selectively inhibited tumor
2020-07-30
Conclusion: Mar-C selectively inhibited tumor growth via the induction of cancer cell senescence and had little chemotherapeutic toxicity, suggesting the potential of Mar-C as a promising anticancer agent. General significance: This study provided evidence to identify a novelty of Mar-C that ex
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br Conclusion br Anti cancer
2020-07-30
5. Conclusion Anti-cancer drug discovery and development are considered as the grand challenges for the pharmaceutical industry. Extremely dynamic mitotic-spindle microtubules indeed remain the most successful and promising targets for anti-cancer therapy. Microtubule-stabilizing agents are con